A family of heat shock proteins, the hsp70 proteins have an average molecular weight of 70 kDa. In most species, there are many proteins that belong to the hsp70 family. Some of these are only expressed under stress conditions (strictly inducible), while some are present in cells under normal growth conditions and are not heat-inducible (constitutive or cognate). Hsp70 proteins can be found in different cellular compartments (nuclear, cytosolic, mitochondrial, endoplasmic reticulum, etc...).

Data Correlations | 1,953 studies

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Normal tissues	Score
Nipple	100
Pericardium	93
Vagina	87
Myometrium	87
Cardia of stomach	86
Cervix of uterus	86

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Compounds	Score
Geldanamycin	100
Gedunin	97
Monorden	95
Piperlonguminine	94
Aids121736	93
C14717	91

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Diseases	Score
Heat exposure	100
Streptococcal infect…	79
Not getting enough s…	79
Starvation	79
Corneal burn	79
Shock	74

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Individual Studies
BY4742 mutant and wildtype yeast - quiescent and non-quiescent populations score: 100 | Saccharomyces cerevisiae |   RNA Expression Quiescent and non-quiescent BY4742 deletion-mutant and wild type strains. Organization: Biology, University of New Mexico Albuqu…	Temperature Upshift in yeast score: 90 | Saccharomyces cerevisiae |   RNA Expression Yeast cells in stationary-phase cultures were exposed to temperature upshift (30C to 39C) with samples harvested every 30-minutes over 8 hours. Organization: Biology, University of New Mexico Albuqu…

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Literature | 8,027 results

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• Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.

  Authors: Mikkel Rohde, Mads Daugaard, Mette Hartvig Jensen, Kristian Helin, Jesper Nylandsted, Marja Jäättelä

  Genes & development 2005 Mar 1

• A small molecule inhibitor of inducible heat shock protein 70.

  Authors: J I-Ju Leu, Julia Pimkina, Amanda Frank, Maureen E Murphy, Donna L George

  Molecular cell 2009 Oct 9

Associated Researchers

Thought leaders and organizations working on research involving heat shock protein 70.

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• Rajinder K Dawra
• Vikas Dudeja
• Ashok K Saluja
• Daniel Borja-Cacho
• Alexzander Asea

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• University of Connecticut
• University of Connecticut Health Center
• Kaohsiung Medical University Chung-Ho Memorial Hospital
• Memorial Sloan-Kettering Cancer Center
• Wake Forest University

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• University of Minnesota
• Institute for Cancer Biology
• University of North Carolina at Chapel Hill
• University of Kentucky
• University of Pennsylvania School of Medicine

Clinical Trials | 8 trials

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• Vaccination Against High Risk Breast Cancer Using Tumor Derived Heat Shock Protein 70

  conditions: Breast Neoplasms

  interventions: Heat Shock Protein 70-peptide complexes (HSP70)

   

• Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic Phase

  conditions: Leukemia,Myeloid, Chronic ; Leukemia,Myeloid,Philadelphia-Positive

  interventions: Heat Shock Protein 70 HSP70

   

News | 2 stories

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• Multimmune GmbH and Boulder Diagnostics partner to develop HSP70 lateral flow point of care test

  News-Medical. - January 13, 2010

• UCLA team heralds groundbreaking hep C drug discovery

  FierceBioResearcher. - January 11, 2010

Community

View All NextBio Users | 4 people

• Yunyun  Jiang

  Graduate Student

  Rice University

• Wynette  Dietz

  PhD Candidate

  University of Minnesota

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