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Description: A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Drug Type: Small Molecule; Approved
Pharmacology: Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism of Action: Halothane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Halothane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Halothane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Indication: For the induction and maintenance of general anesthesia
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Data Correlations | 2 studies

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Genes category icon Genes
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MT-ND1 100 100
ATP2C1 99 99
GABRA1 99 99
GLRA1 99 99
GRIA1 99 99
ATP5D 99 99
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Biogroups category icon Biogroups
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Cardiac Protection Against Ros 100 100
I27 - Inhibitor family I27 (calpas… 100 100
Thiamine Metabolism 100 100
Voltage-dependent potassium channel 99 99
Transcriptional regulator SCAN 99 99
Neurotransmitter-gated ion-channel … 98 98
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Individual Studies

  • Effect of inhaled anesthetic to cultured cortical neurons

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Isolated primary cortical neurons were exposed to anesthetics and DNA oligonucleotide microarrays were used to detect and quantify transcriptional changes in neuronal tissue.

    Authors: Pan Z Jonathan, Wei Huafeng, Hecker G James et al.

    Organization: University of Pennsylvania Philadelphia …

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving halothane.

View All Author iconAuthors
  • J Kent Blasie
  • Jonas S Johansson
  • Joseph Strzalka
  • Jing Liu
  • Andrey Tronin
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Nanjing Medical University
  • Children's Hospital of Philadelphia
  • Ochsner Health System
  • Johns Hopkins University
  • University of Virginia
View All Affiliations icon Organizations
  • University of Pennsylvania
  • University of Oxford
  • University of Leeds
  • University of California
  • Institute of Mathematical Sciences

Clinical Trials | 8 trials

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