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Description: An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.
Drug Type: Small Molecule; Experimental
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Data Correlations | 8 studies

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Genes category icon Genes
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Chi3l3 100 100
UCP1 96 96
ESR2 95 95
IGHG1 95 95
PON1 95 95
CDC2 93 93
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Biogroups category icon Biogroups
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Peptidase, trypsin-like serine and … 100 100
Peptidase S1 and S6, chymotrypsin/H… 100 100
Peptidase S1A, chymotrypsin 99 99
Serine proteases 98 98
PPAR Signaling Pathway 98 98
Cell Cycle G2/M Check Point 98 98
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Individual Studies

  • Effect of 17 beta-estradiol and genistein on Mouse Thymus

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Compared the effects of Estrogen and its analog Genistein on mouse thymus. Endogenous estrogen were minimized by removal of ovaries.

    Authors: Selvaraj V, Bunick D, Finnigan-Bunick C et al.

    Organization: University of Illinois at Urbana-Champai…

  • Biologic responses induced in murine uteri by E2, GEN, and DES

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    To study whether all estrogens are similar, immature Alpk:APfCD-1 mice were treated with arachis oil (AO) vehicle, beta-estradiol (E2), diethylstilbestrol (DES), or genistein (GEN), and sacrificed 72hr after initial dose.

    Authors: Moggs G Jonathan, Ashby John, Tinwell Helen et al.

    Organization: Syngenta Alderley Park Macclesfield Ches…
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Associated Researchers

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Thought leaders and organizations working on research involving genistein.

View All Author iconAuthors
  • Fazlul H Sarkar
  • Raymond C Bergan
  • Li Xu
  • Partha P Banerjee
  • Sanjeev Banerjee
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Messina
  • National Center for Complementary and Alternative Medicine (NCCAM)
  • Northwestern University
  • UNC Lineberger Comprehensive Cancer Center
  • Robert H. Lurie Cancer Center
View All Affiliations icon Organizations
  • Wayne State University School of Medicine
  • Georgetown University Medical Center
  • University of California
  • National Institute of Environmental Health Sciences
  • Robert H. Lurie Cancer Center and Center for Drug Discovery and Chemic…

Clinical Trials | 48 trials

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News | 8 stories

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