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A mesenchymal neoplasm most commonly seen in the gastrointestinal tract. Cases involving tissues outside the gastrointestinal tract have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a specific KIT-expressing and KIT-signaling-driven mesenchymal tumor. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. - 2003

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Data Correlations | 7 studies

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Genes category icon Genes
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KIT 100 100
PDGFRA 100 100
DPP10 90 90
CA2 88 88
NPR3 86 86
LRP1B 86 86
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Biogroups category icon Biogroups
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BAD Pathway 100 100
Tyrosine protein kinase, active sit… 100 100
Tyrosine protein kinase Protein Fam… 99 99
Immunoglobulin subtype 2 99 99
Immunoglobulin Protein Family 98 98
ERK1/ERK2 Mapk Signaling Pathway 97 97
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Individual Studies

  • Mouse Phenotypes - Neoplasms

    Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data

  • Gene expression of human soft tissue sarcoma

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression profiles of 39 human sarcoma samples (GSM 52571-GSM52609) and 15 control samples (GSM52556-GSM52570) were assessed using Affymetrix HG U133A oligonucleotide arrays.

    Authors: Yoon SS, Segal NH, Ryeom SW et al.

    Organization: Massachusetts General Hospital Surgical …
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Associated Researchers

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Thought leaders and organizations working on research involving gastrointestinal stromal tumour.

View All Author iconAuthors
  • George D Demetri
  • Michael C Heinrich
  • Jeffrey A Morgan
  • Brian P Rubin
  • Florian Haller
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • Novartis Pharmaceuticals
  • Novartis
  • European Organization for Research and Treatment of Cancer
  • American College of Surgeons
View All Affiliations icon Organizations
  • Göteborg University
  • Royal Marsden Hospital
  • Institute of Pathology
  • Peter MacCallum Cancer Centre
  • Taussig Cancer Center and the Lerner Research Institute

Clinical Trials | 153 trials

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Community

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