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Description: An orally active testosterone 5-alpha-reductase inhibitor. It is used as a surgical alternative for treatment of benign prostatic hyperplasia. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Finasteride is indicated for the treatment of male pattern hair loss (androgenetic alopecia) in men only. Finasteride is a competitive and specific inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into DHT. Two distinct isozymes are found in mice, rats, monkeys, and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In humans, Type I 5a-reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver. Type I 5a-reductase is responsible for approximately one-third of circulating DHT. The Type II 5a-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.
Mechanism of Action: The mechanism of action of Finasteride is based on its preferential inhibition of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into DHT. Inhibition of Type II 5a-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT concentrations.
Indication: For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: Improve symptoms, reduce the risk of acute urinary retention, reduce the risk of the need for surgery including transurethral resection of the prostat.
Half Life: 4.5 hours (range 3.3-13.4 hours)
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Data Correlations | 4 studies

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Genes category icon Genes
Score Help
SRD5A1 100 100
Mbl1 100 100
RPL18 96 96
545481 92 92
55811 91 91
XIRP1 89 89
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Biogroups category icon Biogroups
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GPCR, family 2, secretin-like 100 100
Neuroactive Ligand Receptor Interac… 100 100
Bile Acid Biosynthesis 99 99
Prostaglandin Synthesis Regulation 99 99
Neurotransmitter-gated ion-channel 99 99
Neurotransmitter-gated ion-channel … 99 99
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Associated Researchers

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Thought leaders and organizations working on research involving finasteride.

View All Author iconAuthors
  • Scott M Lippman
  • Ian M Thompson
  • Charles A Coltman
  • Catherine M Tangen
  • Phyllis J Goodman
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  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Cancer and Leukemia Group B
  • Teva Pharmaceuticals USA
  • Actavis Inc.
  • Mylan Pharmaceuticals
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  • University of Texas Health Science Center at San Antonio
  • University of California
  • University of Bologna
  • University of Toronto
  • Duke University Medical Center

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