estrogen receptor 2 (ER beta)

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of thes...

Data Correlations | 742 studies

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Normal tissues	Score
Zygote	100
Adrenal gland	87
Caudate nucleus	85
Trigeminal ganglion	84
Salivary gland	83
Superior cervical ga…	83

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Compounds	Score
Estradiol 3-[bis(2-c…	100
Genistein	77
Equol	76
Fulvestrant	72
Estradiol	70
Succinylsulfathiazol…	63

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Diseases	Score
Pseudopelade	100
Transitional cell ca…	92
Bordetella	88
ISM - In situ melano…	87
Anomaly of chromosom…	79
Complex V deficiency	79

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Individual Studies

Estrogen receptors mutants affecting ERE binding score: 100 | Homo sapiens |   RNA Expression Response to estradiol-ERalpha, estradiol-ERalpha ERE Binding defective and estradiol-Erbeta and estradiol-ERbeta ERE binding defective mutants. Organization: University of Rochester Rochester NY 146…

Drug target sets for approved compounds score: 100 | Homo sapiens |   Therapeutic The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. Authors: David S Wishart, Craig Knox, An Chi Guo et al. Organization: Department of Computing Science, Univers…

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Literature | 53,831 results

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• Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

  Authors: Takashi Nakamura, Yuuki Imai, Takahiro Matsumoto, Shingo Sato, Kazusane Takeuchi, Katsuhide Igarashi, Yoshifumi Harada, Yoshiaki Azuma, Andree Krust, Yoko Yamamoto,…

  Cell 2007 Sep 7

• Estrogen receptors: how do they signal and what are their targets.

  Authors: Nina Heldring, Ashley Pike, Sandra Andersson, Jason Matthews, Guojun Cheng, Johan Hartman, Michel Tujague, Anders Ström, Eckardt Treuter, Margaret Warner,…

  Physiological reviews 2007 Jul

Associated Researchers

Thought leaders and organizations working on research involving estrogen receptor.

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• Jason S Carroll
• Jan-Ake Gustafsson
• Guojun Cheng
• Patrick Sulem
• Larus Gudmundsson

View All Clinical Trials Sponsors

• AstraZeneca
• Case Comprehensive Cancer Center
• National Heart, Lung, and Blood Institute (NHLBI)
• The Alfred
• University of Kansas

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• Karolinska Institutet
• Dana-Farber Cancer Institute
• Baylor College of Medicine
• University of Wisconsin - Madison
• University of California

Clinical Trials | 824 trials

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• Identifying Genes That Predict Recurrence in Women With Breast Cancer Treated With Chemotherapy

  conditions: Breast Cancer ; Estrogen Receptor ; Her-2 ; Pgr

  interventions: microarray analysis ; protein expression analysis ; immunohistochemistry staining method ; laboratory biomarker analysis

   

• Estrogen Receptor Gene Mutations

  conditions: Mutations ; Hormones

  interventions: none

   

News | 81 stories

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• Estrogen Receptor-Alpha, Breast Cancer Patients And Tamoxifen Response

  Medical News Today. - November 27, 2009

• [Articles] Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial

  Lancet. - January 06, 2010

Community

View All NextBio Users | 3 people

• Jeanne  Maglione

  M.D.

  University of San Diego

• Neli  Basheska

  professor

  University Clinic of Radiotherapy and Oncology, Faculty of Medicine, University Ss Cyril and Metodij

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• Breast Cancer Integrated Knowledge Group

  26 members

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