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Description: Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group. Dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only one. But a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. [Wikipedia]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Dutasteride is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase (5AR), an intracellular enzyme that converts testosterone to 5 alpha-dihydrotestosterone (DHT). Dutasteride is indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland.
Mechanism of Action: Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. The type 2 isoenzyme is primarily active in the reproductive tissues while the type 1 isoenzyme is also responsible for testosterone conversion in the skin and liver. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor.
Indication: For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland.
Half Life: 5 weeks
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Data Correlations | 1 study

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Genes category icon Genes
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SRD5A1 100 100
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Biogroups category icon Biogroups
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Androgen and Estrogen Metabolism 100 100
Bile Acid Biosynthesis 98 98
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    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Thought leaders and organizations working on research involving dutasteride.

View All Author iconAuthors
  • Claus G Roehrborn
  • Paul Siami
  • Francesco Montorsi
  • Stephanie T Page
  • Timothy Wilson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • GlaxoSmithKline
  • University of Washington
  • Beth Israel Deaconess Medical Center
  • Siami, Paul F., M.D.
  • Northwestern University
View All Affiliations icon Organizations
  • Washington University School of Medicine
  • UT Southwestern Medical Center
  • University of Washington
  • Barzilai Medical Center
  • Fred Hutchinson Cancer Research Center

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