A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS. --2002

Data Correlations | 1 study

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Genes	Score
COL11A1	100
INHBA	88
SULF1	86
COL10A1	86
KRT14	86
MFAP5	84

View Top Genes

Biogroups	Score
Collagen helix repeat	100
Collagen triple helix repeat	100
ECM Receptor Interaction	99
Cell Communication	98
MHC class II, alpha/beta chain, N-t…	98
Small Leucine-rich Proteoglycan (SL…	98

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Individual Studies

Ductal Carcinomas in Situ and Invasive Breast Tumors Homo sapiens |   RNA Expression This is a matched-pair analysis of ductal carcinoma in situ (DCIS) and invasive component (IDC) of nine breast ductal carcinoma to identify novel molecular markers characterizing the transition from DCIS to IDC for a better understanding of its molecular biology. Authors: Schütz S Christina, Nieselt Kay, Neubauer Hans Organization: Center for Bioinformatics Tuebingen Depa…

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Literature | 6,089 results

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• Ductal carcinoma in situ with spindle cells: a potential diagnostic pitfall in the evaluation of breast lesions.

  Authors: P H Tan, G G Lui, G Chiang, W M Yap, W T Poh, B H Bay

  Histopathology 2004 Oct

• Combined radioguided nonpalpable lesion localization and sentinel lymph node biopsy for early breast carcinoma.

  Authors: Alfredo C S D Barros, Maria A C Barros, Felipe E Andrade, Lincon J Mori, Paulo A Costa, Peng Y Sheng, Christina H T Pelizon

  Annals of surgical oncology 2007 Apr

Associated Researchers

Thought leaders and organizations working on research involving ductal carcinoma in situ.

View All Authors

• Mehra Golshan
• Karen Chew
• Virginia L Ernster
• Beth A Virnig
• Janet S de Moor

View All Clinical Trials Sponsors

• UCSF Helen Diller Family Comprehensive Cancer Center
• Memorial Sloan-Kettering Cancer Center
• National Surgical Adjuvant Breast and Bowel Project (NSABP)
• Dana-Farber Cancer Institute
• Sidney Kimmel Comprehensive Cancer Center

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• Dana-Farber Cancer Institute
• Singapore General Hospital
• University of California
• Yale University School of Medicine
• Hospital Sírio Libanês

Clinical Trials | 344 trials

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• Neoadjuvant Herceptin for Ductal Carcinoma In Situ of the Breast

  conditions: Ductal Carcinoma In Situ

  interventions: Herceptin (Trastuzumab)

   

• Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS)

  conditions: Ductal Carcinoma In Situ

  interventions: Carboplatin i.d. Days 1 & 15 ; Carboplatin i.d. Day 1; Normal Saline i.d. Day 15 ; Normal Saline

   

News | 19 stories

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• Ductal Carcinoma In Situ And Its Many Unanswered Questions

  Medical News Today. - January 14, 2010

• Researchers tackle ductal carcinoma in situ and its many unanswered questions

  Science Daily. - January 18, 2010

Community

View All NextBio Users | 2 people

• DIMITRIOS  DRAGOUMIS

• Jeanne  Maglione

  M.D.

  University of San Diego

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