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Description: A selective alpha-1-adrenergic blocker that lowers serum cholesterol. It is also effective in the treatment of hypertension. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Doxazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Doxazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Doxazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Doxazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Doxazosin results from a decrease in systemic vascular resistance and the parent compound Doxazosin is primarily responsible for the antihypertensive activity.
Mechanism of Action: Doxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
Indication: For treatment and management of Hypertension and urinary obstruction symptoms of BPH.
Half Life: 22 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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ADRA1A 100 100
MEX3D 85 85
ZNF652 79 79
SCAMP1 78 78
OAS1 77 77
PTGER3 77 77
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Biogroups category icon Biogroups
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ENV polyprotein (coat polyprotein) 100 100
I8 - chymotrypsin/elastase inhibit… 98 98
I21 - secretogranin V 96 96
Calcium Regulation In Cardiac Cells 95 95
Calcium Signaling Pathway 94 94
Myosin head, motor region 92 92
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Individual Studies

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    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving doxazosin.

View All Author iconAuthors
  • Barry R Davis
  • Paula T Einhorn
  • ALLHAT Collaborative Research Group
  • Natasha Kyprianou
  • Henry R Black
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Pfizer
  • Samsung Medical Center
  • Hospital Authority, Hong Kong
View All Affiliations icon Organizations
  • University of Kentucky College of Medicine
  • Jichi Medical University School of Medicine
  • Imperial College London
  • University of Camerino
  • Nagoya City University Graduate School of Medical Sciences

Clinical Trials | 42 trials

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