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Description: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Mechanism of Action: Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Indication: For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
Half Life: 18.5 hours
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Data Correlations | 6 studies

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Genes category icon Genes
Score Help
399668 100 100
LAMP3 90 90
FBXO5 88 88
QSER1 86 86
SPATA18 84 84
CA2 83 83
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Biogroups category icon Biogroups
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Helix-loop-helix DNA-binding 100 100
Basic helix-loop-helix dimerisation… 100 100
Cyclin-like F-box 99 99
Basic-leucine zipper (bZIP) transcr… 99 99
Keratin, type I 99 99
Cell surface antigen 98 98
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving daunorubicin.

View All Author iconAuthors
  • Guisheng Zhang
  • Lawrence D Mayer
  • Wasim K Bleibel
  • David Bermudes
  • Rob Pieters
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Cancer and Leukemia Group B
  • Southwest Oncology Group
  • Celator Pharmaceuticals
  • Acute Leukemia French Association
  • Arthur G. James Cancer Hospital & Richard J. Solove Research Institute
View All Affiliations icon Organizations
  • University of Chicago
  • Celator Pharmaceuticals Corporation
  • Sojo University
  • Ohio State University
  • Madurai Kamaraj University

Clinical Trials | 228 trials

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