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1. inadequacy of the heart so that as a pump it fails to maintain the circulation of blood, with the result that congestion and edema develop in the tissues; SEE ALSO forward heart failure, backward heart failure, right ventricular failure, left ventricular failure. SYN cardiac failure, cardiac insufficiency, congestive heart failure, myocardial insufficiency. 2. resulting clinical syndromes including shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales in various combinations.

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Data Correlations | 5 studies

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Genes category icon Genes
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ADRB1 100 100
ADRA2C 100 100
CHI3L1 100 100
HLA-DQB1 99 99
TNF 98 98
NPPA 95 95
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Biogroups category icon Biogroups
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Cytokine Cytokine Receptor Interact… 100 100
Regulation of Actin Cytoskeleton 97 97
Local Acute Inflammatory Response P… 97 97
Alternative Complement Pathway 97 97
Leukocyte Transendothelial Migratio… 97 97
Oxidative Phosphorylation 97 97
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Individual Studies

  • A predictive heart failure expression profile in Ren2 rat left ventricles

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    The intercalated disc of cardiac myocytes is emerging as a crucial structure in the heart. Loss of intercalated disc proteins like N-cadherin causes lethal cardiac abnormalities, mutations in intercalated disc proteins cause human cardiomyopathy. A comprehensive screen for novel mechanisms in failin…

    Authors: van Erk Arie, Schroen Blanche, Pinto Yigal

    Organization: University Maastricht BiGCaT Bioinformat…

  • Heart failure in TNF-alpha transgenics

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Cardiac-specific TNF-alpha transgenic mice are an excellent model to study the pathologenesis of heart failure. Affymetrix U74V2A was used to analyze the gene expression profile of male and female wildtype FVB and TNF-alpha transgenic mice at the time point of compensated hypertrophy and dilated hea…

    Authors: Tang H Z, Feldman M A, Tang H Zhong et al.

    Organization: Thomas Jefferson University Medicine Cen…
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Associated Researchers

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Thought leaders and organizations working on research involving congestive heart failure.

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  • Stanley Nattel
  • Yung-Hsin Yeh
  • Sherif F Nagueh
  • Harjot K Saini-Chohan
  • Yingjie Chen
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Massachusetts General Hospital
  • Ohio State University
  • Otsuka Pharmaceutical Development & Commercialization, Inc.
  • Department of Veterans Affairs
View All Affiliations icon Organizations
  • University of Minnesota Medical School
  • Montreal Heart Institute and Université de Montréal
  • University of Manitoba
  • Research Center Montreal Heart Institute and Université de Montréal
  • Methodist Hospital Research Institute

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