Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

Data Correlations | 2,248 studies

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Normal tissues	Score
Pericardium	100
Synovial membrane	99
Mesenteric lymph nod…	97
Uterine tube	91
Bronchus	86
Fetal organ	82

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Compounds	Score
Oncostatin M	100
Resiquimod	85
Bute Hydrocarbon	80
Medroxyprogesterone …	79
Infliximab	78
Crystalbumins	77

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Diseases	Score
Crohn's disease of l…	100
Peripheral T-cell ly…	96
Infertility due to a…	92
Adrenal carcinoma	90
Infertility due to i…	88
Liver carcinoma	88

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Individual Studies
Gene expression profiling of experimental asthma induced by OVA challenge score: 100 | Mus musculus |   RNA Expression Three groups of mice (6 mice/group) were sensitized and challenged with allergen (OVA), one group (control group) was sensitized and challenged with placebo (PBS) and served as a control. Source: NextBio Library/Immune response and infection	Human and macacque liver and muscle tissues score: 88 | Homo sapiens |   RNA Expression Comparison of liver and muscle tissues from human and macacque species. Source: NextBio Library/Atlas - Organs, tissues and cell types

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Literature | 67,573 results

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• The structure of complement C3b provides insights into complement activation and regulation.

  Authors: A Abdul Ajees, K Gunasekaran, John E Volanakis, Sthanam V L Narayana, Girish J Kotwal, H M Krishna Murthy

  Nature 2006 Nov 9

• Complement activation and inhibition: a delicate balance.

  Authors: A P Sjöberg, L A Trouw, A M Blom

  Trends in immunology 2009 Feb

Associated Researchers

Thought leaders and organizations working on research involving complement activation.

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• John D Lambris
• Piet Gros
• Bert J C Janssen
• Markus Huber-Lang
• Jos A G van Strijp

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• National Heart, Lung, and Blood Institute (NHLBI)
• Mayo Clinic
• Austin Health
• Vanderbilt University
• Cubist Pharmaceuticals

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• Utrecht University
• University Medical Center Utrecht
• Center for Biophysical Sciences and Engineering
• University of Copenhagen
• University of Ulm Medical School

Clinical Trials | 53 trials

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• Complement Activation and Central Nervous System Injury After Coronary Artery Surgery

  conditions: Coronary Artery Bypass Grafting

  interventions: heparin-coated cardiopulmonary bypass

   

• Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease

  conditions: Atypical Hemolytic Uraemic Syndrome.

  interventions: none

   

News | 1 story

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• ORIGINAL ARTICLE: C3 Polymorphisms and Allograft Outcome in Renal Transplantation

  NEJM.

Community

View All NextBio Users | 1 person

• Sreenivasan  Rajamoni Nadar

  Research Fellow/ Scientist

  National Institutes of Health

NextBio Groups

• No NextBio groups were found for “complement activation”.
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