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Description: Clioquinol was withdrawn in 1983 due to neurotoxicity.
Drug Type: Small Molecule; Withdrawn
Pharmacology: Clioquinol is a broad-spectrum antibacterial with antifungal properties. Application of clioquinol to extensive or eroded areas of the skin may lead to increased protein-bound iodine (PBI) levels within 1 week. In addition, elevated PBI levels may occur when relatively small areas of the skin are treated with clioquinol for more than 1 week.
Mechanism of Action: Clioquinol is bacteriostatic, however, the precise mechanism of its action is unknown.
Indication: Used as a topical antifungal treatment.
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Data Correlations | 7 studies

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Genes category icon Genes
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MT1M 100 100
MT1F 98 98
MT1G 92 92
MT1X 92 92
MT1H 89 89
CYP1A1 89 89
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Biogroups category icon Biogroups
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Growth factor, cystine knot 100 100
FOSB Gene Expression and Drug Abuse 99 99
Histone core 99 99
Cytochrome P450, E-class, group I 98 98
TNFR2 Pathway 98 98
Tryptophan Metabolism 97 97
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Hydrocortisone treated scar and keloid fibroblasts

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Keloids are benign tumors of the dermis that form during a protracted wound healing process. Susceptibility to keloid formation occurs predominantly in people of African and Asian descent. The key alteration(s) responsible for keloid formation has not been identified and there is no satisfactory t…

    Authors: Smith Joan, Boone Braden, Opalenik Susan et al.

    Organization: Vanderbilt University Medicine 519 Light…
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Associated Researchers

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Thought leaders and organizations working on research involving clioquinol.

View All Author iconAuthors
  • Wei-Qun Ding
  • Ashley I Bush
  • Robert A Cherny
  • Colin L Masters
  • Stuart E Lind
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • University Health Network, Toronto
  • University Hospital, Lille
  • Novum
  • University of California, San Francisco
View All Affiliations icon Organizations
  • University of Oklahoma Health Sciences Center
  • University of Melbourne
  • Buck Institute for Age Research
  • Wayne State University
  • Georgetown University

Clinical Trials | 7 trials

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