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Description: A broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Mechanism of Action: The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Indication: For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
Half Life: 4 hours
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Data Correlations | 4 studies

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Genes category icon Genes
Score Help
RGN 100 100
FBXW5 94 94
RGD1310428_predicted 92 92
RBM8A 91 91
C2orf3 90 90
AQP3 89 89
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Biogroups category icon Biogroups
Score Help
Regulation of CK1/CDK5 by Type 1 Gl… 100 100
Smooth Muscle Contraction 100 100
Serine/threonine protein kinase, ac… 100 100
Zinc finger, RING-type 99 99
Transcription Regulation by Methylt… 98 98
Tetratricopeptide-like helical 98 98
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Individual Studies

  • Liver Pharmacology and Xenobiotic Response Repertoire

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…

  • Comparison of Primary Human Hepatocytes to HepG2 Cells

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Primary human hepatocytes (PHH) are a main instrument in drug metabolism research and in the prediction of drug-induced phase I/II enzyme induction in humans. The HepG2 liver-derived cell line is commonly used as a surrogate for human hepatocytes, but their use in ADME and toxicity studies can be l…

    Authors: Liguori J Michael, Blomme A Eric, Waring F Jeffrey

    Organization: Abbott Laboratories Cellular and Molecul…
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Associated Researchers

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Thought leaders and organizations working on research involving ciprofloxacin.

View All Author iconAuthors
  • Antti Sukura
  • Bei Wen
  • Zhiguo Pei
  • Jacob Strahilevitz
  • Jean-Marie Pagès
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Bayer
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  • Mylan Pharmaceuticals
  • International Centre for Diarrhoeal Disease Research, Bangladesh
  • National Institute of Allergy and Infectious Diseases (NIAID)
View All Affiliations icon Organizations
  • Chang Gung University College of Medicine
  • University of Helsinki
  • University College Dublin
  • Chang Gung Memorial Hospital
  • Communicable Disease Surveillance Centre

Clinical Trials | 201 trials

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