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The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic: an initial indolent chronic phase is followed by accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001).

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Data Correlations | 12 studies

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Genes category icon Genes
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PTPN11 100 100
SIPA1 100 100
DOK2 100 100
EVI1 100 100
CCDC6 100 100
RPL22 100 100
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Biogroups category icon Biogroups
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Immunoglobulin subtype 100 100
Methane Metabolism 100 100
Immunoglobulin/major histocompatibi… 100 100
Signaling Pathway From G-protein Fa… 99 99
Stilbene Coumarine and Lignin Biosy… 99 99
Prostaglandin and Leukotriene Metab… 98 98
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Individual Studies

  • Comparative analysis of a CML cell line resistant to cyclophosphamide

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progressi…

    Authors: Bao F, Polk P, Nordberg ML et al.

    Organization: LSU Health Sciences Center Medicine Divi…

  • K562 Gene Expression Control vs 1R-Chl treatments

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    To determine whether the polyamide-Chl conjugate 1R-Chl would cause similar changes in global gene expression in K562 cells, affymetrix gene chip analysis was performed using 1R-Chl. Through class comparison analysis, 1R-Chl affected the levels of transcription and genes of interest were determined…

    Authors: Gottesfeld M Joel, Dervan B Peter, Chou C James et al.

    Organization: The Scripps Research Institute Molecular…
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Associated Researchers

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Thought leaders and organizations working on research involving chronic myeloid leukemia.

View All Author iconAuthors
  • Jorge Cortes
  • Susan O'Brien
  • Hagop Kantarjian
  • Andreas Hochhaus
  • Hagop M Kantarjian
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Poitiers University Hospital
  • Novartis Pharmaceuticals
  • University of Bologna
  • M.D. Anderson Cancer Center
  • Hadassah Medical Organization
View All Affiliations icon Organizations
  • University of Texas M. D. Anderson Cancer Center
  • Fred Hutchinson Cancer Research Center
  • MD Anderson Cancer Center
  • University of Bologna
  • University of Massachusetts Medical School

Clinical Trials | 751 trials

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