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Description: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. [PubChem]
Drug Type: Small Molecule; Experimental
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Data Correlations | 11 studies

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Genes category icon Genes
Score Help
SQLE 100 100
IDI1 96 96
CYP51A1 93 93
SC4MOL 87 87
HMGCS1 87 87
MVD 85 85
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Biogroups category icon Biogroups
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Cholesterol Biosynthesis 100 100
Biosynthesis of Steroids 100 100
Tetrachloroethene Degradation 98 98
Steroid Biosynthesis 98 98
Lipase, active site 98 98
Lipase/lipooxygenase, PLAT/LH2 98 98
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Individual Studies

  • Differential gene expression in BALB/c Npc1-/- and Npc1+/+ cerebellum

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Purkinje cells (PC) of the cerebellum degenerate in adult mice with mutations in the Niemann-Pick type C (NPC) disease 1 (Npc1) gene. We subjected BALB/c Npc1+/+ and Npc1-/- mouse cerebella from an early and a later time point of PC degeneration to a genome-wide microarray gene expression analysis. …

    Authors: Distl R, Kuban R

    Organization: Charité Universitätsmedizin Berlin Insti…

  • Analysis of Niemann-Pick type C fibroblast with I1061T NPC1 mutation

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Primary skin fibroblasts from four Niemann-Pick type C patients homozygous for the I1061T mutation and four control individuals were cultured under identical conditions in DMEM containing 10% fetal bovine serum. Cells were harvested at 50-70% confluency. mRNA was isolated with the FastTrack 2.…

    Authors: Reddy Jon

    Organization: Stanford Microarray Database (SMD) Stanf…
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Associated Researchers

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Thought leaders and organizations working on research involving cholesterol.

View All Author iconAuthors
  • Martin C Carey
  • Mauro Amato
  • Jeffrey T Billheimer
  • Jose M Ordovas
  • Sekar Kathiresan
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Merck
  • National Heart, Lung, and Blood Institute (NHLBI)
  • AstraZeneca
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • Oregon Health and Science University
View All Affiliations icon Organizations
  • University of Texas Southwestern Medical Center
  • Massachusetts General Hospital
  • Liver Center and Gastroenterology Division
  • Brigham and Women's Hospital
  • University of Pennsylvania School of Medicine

Clinical Trials | 2,548 trials

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