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Description: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.
Mechanism of Action: Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Indication: For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care.
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Data Correlations | 1 study

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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving chlorhexidine.

View All Author iconAuthors
  • Luke C Mullany
  • Joanne Katz
  • L Tjäderhane
  • James M Tielsch
  • Subarna K Khatry
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Johns Hopkins Bloomberg School of Public Health
  • National Institute of Dental and Craniofacial Research (NIDCR)
  • All India Institute of Medical Sciences, New Delhi
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • University of British Columbia
View All Affiliations icon Organizations
  • University of Campinas
  • Johns Hopkins University
  • University of Witwatersrand
  • Johns Hopkins Bloomberg School of Public Health
  • John Hopkins Bloomberg School of Public Health

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