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Description: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Carbamazepine, an anticonvulsant structurally similar to tricyclic antidepressants, is used to treat partial seizures, tonic-clonic seizures, pain of neurologic origin such as trigeminal neuralgia, and psychiatric disorders including manic-depressive illness and aggression due to dementia.
Mechanism of Action: Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties.
Indication: For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Half Life: 25-65 hours
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Data Correlations | 5 studies

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Genes category icon Genes
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SCN5A 100 100
STAC3 100 100
DDIT4L 96 96
ABCC3 93 93
ATF3 91 91
GRIN2C 89 89
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Biogroups category icon Biogroups
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Neuroactive Ligand Receptor Interac… 100 100
Calcium Signaling Pathway 99 99
Focal Adhesion 99 99
WNT Signaling Pathway 99 99
Small Leucine-rich Proteoglycan (SL… 99 99
Immunoglobulin E-set 99 99
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Mouse cerebella from pups exposed to PTU to induce hypothyroidism

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    To investigate the molecular basis of thyroid hormone action on the developing brain, pregnant dams were treated with 0.1% 6-propyl-2-thiouracil (PTU) to produce hypothyroid pups.

    Source: NextBio Library/Metabolic disorders and Obesity
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Associated Researchers

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Thought leaders and organizations working on research involving carbamazepine.

View All Author iconAuthors
  • Ilo E Leppik
  • Stephen G Waxman
  • Graeme J Sills
  • D W Chadwick
  • Sunao Kaneko
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute on Drug Abuse (NIDA)
  • Centre of Chinese Medicine, Georgia
  • Validus Pharmaceuticals
  • UCB
  • Eisai Inc.
View All Affiliations icon Organizations
  • University of Minnesota
  • University of Liverpool
  • University of the Ryukyus
  • Yale University School of Medicine
  • University of Florida

Clinical Trials | 1,120 trials

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