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Description: Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Drug Type: Small Molecule; Approved
Pharmacology: Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.
Mechanism of Action: Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties.
Indication: For the treatment of depression
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Data Correlations | 2 studies

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Genes category icon Genes
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HTR2A 100 100
DRD2 100 100
DRD1 100 100
SLC6A4 100 100
HTR2C 100 100
HTR2B 100 100
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Biogroups category icon Biogroups
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I2 - Inhibitor family I2 (Kunitz-B… 100 100
Tudor 99 99
Monoamine GPCRs 99 99
Inositol Metabolism 99 99
G-Protein Signaling Through Tubby P… 98 98
Peptidase M12B, propeptide 97 97
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving cantor.

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  • Harvey Cantor
  • Charles R Cantor
  • Rita M Cantor
  • Daniel H Geschwind
  • Sharon B Cantor
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  • Indiana University School of Medicine
  • H. Lee Moffitt Cancer Center and Research Institute
  • Mount Sinai School of Medicine
  • Novartis
  • Indiana University
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  • Dana-Farber Cancer Institute
  • University of California
  • Boston University
  • San Raffaele Telethon Institute for Gene Therapy
  • University of California, San Diego

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