An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK, high risk of VENTRICULAR TACHYCARDIA or VENTRICULAR FIBRILLATION, SYNCOPAL EPISODE, and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.

Data Correlations | 2 studies

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Genes	Score
SCN5A	100
CACNA1C	76
CACNB2	76
GPD1L	76

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Biogroups	Score
Ion transport	100
IQ calmodulin-binding region	86
MAPK Signaling Pathway	84

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Individual Studies

Mouse Phenotypes - Conduction disorder of the heart Mus musculus |   Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data

OMIM - Conduction disorder of the heart Homo sapiens |   Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

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Literature | 1,508 results

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• Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry.

  Authors: V Probst, C Veltmann, L Eckardt, P G Meregalli, F Gaita, H L Tan, D Babuty, F Sacher, C Giustetto, E Schulze-Bahr,…

  Circulation 2010 Feb 9

• High-density substrate mapping in Brugada syndrome: combined role of conduction and repolarization heterogeneities in arrhythmogenesis.

  Authors: P D Lambiase, A K Ahmed, E J Ciaccio, R Brugada, E Lizotte, S Chaubey, Ron Ben-Simon, A W Chow, M D Lowe, W J McKenna

  Circulation 2009 Jul 14

Associated Researchers

Thought leaders and organizations working on research involving brugada syndrome.

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• Charles Antzelevitch
• Pedro Brugada
• Arthur A M Wilde
• Ramon Brugada
• Josep Brugada

View All Clinical Trials Sponsors

• Medtronic Bakken Research Center
• University of Heidelberg
• Teva Pharmaceutical Industries
• National Heart, Lung, and Blood Institute (NHLBI)
• Assistance Publique - Hôpitaux de Paris

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• Masonic Medical Research Laboratory
• Okayama University Graduate School of Medicine
• Academic Medical Center
• University College Hospital
• Calicut Medical College

Clinical Trials | 29 trials

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• DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome

  conditions: Brugada Syndrome

  interventions: 3,4-Di-amino-Pyridine ; placebo

   

• Hydroquinidine Versus Placebo in Patients With Brugada Syndrome

  conditions: Brugada Syndrome

  interventions: hydroquinidine ; placebo (sugar)

   

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