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Description: Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)
Drug Type: Small Molecule; Approved
Pharmacology: L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent.
Mechanism of Action: Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.
Indication: For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
Half Life: 2-3.5 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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CHRM1 100 100
CHRM2 100 100
CHRM3 100 100
CHRM4 100 100
CHRM5 100 100
CASP2 90 90
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Biogroups category icon Biogroups
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G-Protein Signaling Through Tubby P… 100 100
Monoamine GPCRs 98 98
Neuroactive Ligand Receptor Interac… 96 96
Calcium Regulation In Cardiac Cells 95 95
Calcium Signaling Pathway 95 95
Blockade of Neurotransmitter Relase… 90 90
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving atropine.

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  • Jonathan M Holmes
  • Pediatric Eye Disease Investigator Group
  • Michael X Repka
  • Raymond T Kraker
  • Roy W Beck
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Eye Institute (NEI)
  • Medical University of Vienna
  • Mayo Clinic
  • National Institute on Aging (NIA)
  • Magna Pharmaceuticals, Inc.
View All Affiliations icon Organizations
  • Douglas Mental Health University Institute
  • Jaeb Center for Health Research
  • San Diego VA Health Care System
  • Singapore National Eye Center
  • University of Oxford

Clinical Trials | 149 trials

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