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A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.

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Data Correlations | 77 studies

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Diseases category icon Diseases
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Neoplasm of thymus 100 100
Aging 48 48
High fat diet 43 43
Obesity 41 41
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Geneticperturbations category icon Gene perturbations
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PCDH12 gene 100 100
NFKBIB gene 89 89
Tcf1 gene 88 88
ADRA2B gene 87 87
CCL20 gene 85 85
GATA3 gene 84 84
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Compounds category icon Compounds
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Adenosine Triphospha… 100 100
Glutamate 97 97
Lpa 97 97
Paf Acether 96 96
Neurokinin B 94 94
SID 10487208 92 92
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Individual Studies

  • Tumor-associated macrophages from mouse mammary tumors

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Tumor-associated macrophages from late-stage mouse mammary tumors compared to splenic macrophages from non-tumor-bearing littermate controls.

    Source: NextBio Library/Oncology

  • Genes regulated by VE-Cadherin

    score: 9090 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive).

    Authors: Taddei A, Conti A, Orsenigo F et al.

    Organization: IFOM-IEO-CAMPUS Via Adamello, 16 Milan 2…
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Associated Researchers

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Thought leaders and organizations working on research involving apoptosome.

View All Author iconAuthors
  • Francesco Cecconi
  • Xiaodong Wang
  • Yigong Shi
  • Xuejun Jiang
  • Young Hyun Yoo
View All Affiliations icon Organizations
  • Princeton University
  • Duke University Medical Center
  • University of Texas Southwestern Medical Center
  • Smurfit Institute
  • Laboratory of Molecular Neuroembryology

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