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Description: An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Mechanism of Action: Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly.
Indication: For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Half Life: 20 hours
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Data Correlations | 9 studies

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Genes category icon Genes
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PPARA 100 100
545481 100 100
ACOT1 94 94
XIRP1 93 93
EHHADH 89 89
CIDEA 88 88
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Biogroups category icon Biogroups
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PPAR Signaling Pathway 100 100
Fatty Acid Metabolism 97 97
Beta-Oxidation of Fatty Acids 96 96
PPAR-a Pathway 96 96
Cyclin E Destruction Pathway 95 95
Valine Leucine and Isoleucine Degra… 95 95
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving antara.

View All Author iconAuthors
  • Anthony C Keech
  • Marja-Riitta Taskinen
  • FIELD study investigators
  • Robert S Rosenson
  • Anne Hiukka
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Solvay Pharmaceuticals
  • Merck
  • GlaxoSmithKline
  • University of Florida
  • Ranbaxy Laboratories Limited
View All Affiliations icon Organizations
  • University of Sydney
  • University of Michigan
  • University of Western Australia
  • University of Ioannina
  • Gachon Medical School

Clinical Trials | 137 trials

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News | 1 story

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