NextBio

Help
Description: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name 'penicillin' can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
Indication: For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
View Complete Description



Data Correlations | 1 study

Help for Data Correlations View All

Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving ampicillin.

View All Author iconAuthors
  • Irit Carmi-Levy
  • P L Toutain
  • Gillian Kay
  • A Bousquet-Mélou
  • Qun Dang
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Johns Hopkins Bloomberg School of Public Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • International Centre for Diarrhoeal Disease Research, Bangladesh
  • Children's Mercy Hospital Kansas City
  • Pfizer
View All Affiliations icon Organizations
  • Hebrew University-Hadassah Medical School
  • University of California
  • University of Bonn
  • Hospital Universitari Vall d'Hebron
  • Tsinghua University

Community

Help for Community
View All NextBio Users | 3 people
NextBio Groups

  • No NextBio groups were found for “ampicillin”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio