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Description: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Mechanism of Action: Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
Indication: Used to treat potentially life threatening fungal infections.
Half Life: An elimination half-life of approximately 15 days follows an initial plasma half-life of about 24 hours.
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Data Correlations | 3 studies

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Genes category icon Genes
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KBTBD10 100 100
TNNI1 97 97
TNNC1 95 95
VASH2 92 92
MYH3 91 91
MSTN 90 90
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Biogroups category icon Biogroups
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Purine Metabolism 100 100
Cholesterol Biosynthesis 100 100
Biosynthesis of Steroids 100 100
Actin/actin-like 99 99
Terpenoid Biosynthesis 99 99
Histone core 98 98
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Individual Studies

  • Fetal myoblast differentiation - time course

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Fetal myoblasts represent an important source of myogenic stem cells. Analysis of undifferentiated myoblasts and comparison to their cognate differentiated progeny will allow the ascertainment of genes that are important for maintaining myogenic stem cells.

    Organization: Ontario Genomics Innovation Centre (OGIC…

  • Yeast resistance to antifungal drugs: fluconazole and amphotericin B

    Saccharomyces cerevisiae Saccharomyces cerevisiae | RNA Expression   RNA Expression

    In this study, replicate populations of Saccharomyces cerevisiae were evolved in increasing concentrations of AmB over hundreds of generations to yield resistant types among which there were permanent changes in gene-expression. Also Three populations at 100 and 400 generations of evolution in in…

    Authors: Anderson B James, Sirjusingh Caroline, Syed Nazia et al.

    Organization: University of Toronto Biology James B. A…
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Associated Researchers

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Thought leaders and organizations working on research involving amphotericin b.

View All Author iconAuthors
  • Nobuaki Matsumori
  • Dimitrios P Kontoyiannis
  • Thomas J Walsh
  • Josep Guarro
  • Tohru Oishi
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • Banaras Hindu University
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • University of Pittsburgh
  • Astellas Pharma Inc
View All Affiliations icon Organizations
  • Innsbruck Medical University
  • Osaka University
  • Universitat Rovira i Virgili
  • University of Houston College of Pharmacy
  • National Cancer Institute

Clinical Trials | 267 trials

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