NextBio

Help

A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities 2) AML with multilineage dysplasia 3) Therapy-related AML 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML has been recently reduced from 30% (French-American-British [FAB] classification) to 20% (WHO classification). (WHO, 2001)

View Complete Description



Data Correlations | 56 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
HOXA9 100 100
CTSG 100 100
MN1 100 100
CEBPA 100 100
GATA1 100 100
RUNX1T1 100 100
View Top Genes
Biogroups category icon Biogroups
Score Help
Hematopoietic Cell Lineage 100 100
I43 - oprin 100 100
Natural Killer Cell Mediated Cytoto… 99 99
All Peptidase Inhibitors 99 99
Hemoglobin's Chaperone 98 98
C-type lectin 98 98
View Top Biogroups

Individual Studies

  • Effects of farnesyltransferase inhibitors on acute myeloid leukemia

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Currently there is no method available to predict response to farnesyltransferase inhibitors (FTI). We analyzed gene expression profiles from the bone marrow of patients from a phase 2 study of the FTI tipifarnib, in older adults with previously untreated acute myeloid leukemia (AML). The RASGRP1:AP…

    Authors: Raponi Mitch

    Organization: Veridex, LLC 3210 Merryfield Row San Die…

  • CD34 positive and negative fractions from AML patients

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    CD34-positive and negative fractions were used for genomic DNA preparation, which was hybridized to HGU133 Plus 2.0 arrays.

    Organization: Jichi Medical University Division of Fun…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving acute myeloid leukemia.

View All Author iconAuthors
  • Michael Andreeff
  • Bob Löwenberg
  • Guido Marcucci
  • John F DiPersio
  • Hartmut Döhner
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Ulm
  • Wyeth
  • University Hospital Muenster
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  • Eisai Inc.
View All Affiliations icon Organizations
  • Ohio State University
  • University of Texas M D Anderson Cancer Center
  • Erasmus University Medical Center
  • University of Ulm
  • Erasmus MC-Sophia Children's Hospital

Clinical Trials | 959 trials

Help for Clinical Trials View All

News | 6 stories

Help for News View All

Community

Help for Community
View All NextBio Users | 2 people
NextBio Groups

  • No NextBio groups were found for “acute myeloid leukemia”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio