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Description: Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate like properties.
Drug Type: Small Molecule; Approved
Pharmacology: Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex. Subunit modulation of the GABABZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor.
Mechanism of Action: Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.
Indication: For the short-term treatment of insomnia.
Half Life: Elimination half life is approximately 5 hours (range 3.8 to 6.5 hours) and is prolonged to 11.9 hours in patients with hepatic insufficiency.
Molecular weight: 388.808 g/mol
Molecular formula: C17H17ClN6O3
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Data Correlations | 2 studies

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Genes category icon Genes
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TSPO 100 100
CA3 100 100
PON1 92 92
RGN 84 84
GK 82 82
FGF9 82 82
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Biogroups category icon Biogroups
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Secretin Like 100 100
GPCR, family 2, extracellular regio… 99 99
Extracellular ligand-binding recept… 99 99
Neuroactive Ligand Receptor Interac… 99 99
Basal Transcription Factors 98 98
Small Ligand GPCRs 97 97
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Individual Studies

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Associated Researchers

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Thought leaders and organizations working on research involving Zopiclone.

View All Author iconAuthors
  • Kendyl Schaefer
  • Thomas Roth
  • Robert Rubens
  • Michael H Chase
  • Annemiek Vermeeren
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Sepracor, Inc.
  • Massachusetts General Hospital
  • University of California, San Diego
  • University of Medicine and Dentistry New Jersey
  • Eisai Inc.
View All Affiliations icon Organizations
  • Maastricht University
  • Massachusetts General Hospital
  • Walter Reed Army Medical Center
  • Karolinska Institutet
  • Mount Sinai School of Medicine

Clinical Trials | 73 trials

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