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Description: Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Drug Type: Biotech; Approved
Pharmacology: The pharmacokinetics of ZOLADEX have been determined in both male and female healthy volunteers and patients. In these studies, ZOLADEX was administered as a single 250µg (aqueous solution) dose and as a single or multiple 3.6 mg depot dose by subcutaneous route.
Mechanism of Action: ZOLADEX is a synthetic decapeptide analogue of LHRH. ZOLADEX acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.
Indication: Breast cancer; Prostate carcinoma; Endometriosis
Half Life: 4-5 hours
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Data Correlations | 1 study

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Genes category icon Genes
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LHCGR 100 100
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Biogroups category icon Biogroups
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Leucine-rich repeat, cysteine-rich … 100 100
Peptide GPCRs 98 98
Calcium Signaling Pathway 95 95
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving Zoladex.

View All Author iconAuthors
  • Peter Hedden
  • A Nikolov
  • Makoto Matsuoka
  • E Tiufekchieva
  • Tohru Ariizumi
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • AstraZeneca
  • Ferring Pharmaceuticals
  • Dana-Farber Cancer Institute
  • European Organization for Research and Treatment of Cancer
  • University of Tampere
View All Affiliations icon Organizations
  • University College London
  • Nagoya University
  • University of Nottingham
  • Cardiff University
  • Karolinska Institute and University Hospital

News | 2 stories

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