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Description: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.
Mechanism of Action: Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
Indication: For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
Half Life: 5-15 minutes
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Data Correlations | 7 studies

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Genes category icon Genes
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CA3 100 100
GCKR 94 94
SLC22A8 90 90
RGD1561637_predicted 89 89
EDNRA 84 84
PGGT1B 83 83
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Biogroups category icon Biogroups
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Tetrachloroethene Degradation 100 100
PAS Protein Family 98 98
Parkin Pathway 98 98
Rab Pathway 98 98
Cyclic nucleotide-binding 98 98
RmlC-like jelly roll fold 98 98
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Individual Studies

  • ADH-1 and melphalan effects on melanoma

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    To identify patterns of change in gene expression that correlated with drug treatment (saline control, ADH-1 alone, melphalan alone and ADH-1 plus melphalan) in our animal model of regional therapy for extremity melanoma we evaluated gene expression using microarray genechips.

    Authors: Augustine CK, Tyler DS

    Organization: Duke University Medical Center Surgery V…

  • Base excision repair-APN1 knockout Yeast overexpressing MAG and APN1

    Saccharomyces cerevisiae Saccharomyces cerevisiae | RNA Expression   RNA Expression

    We are investigating the transcriptional response of yeast to modulation of the expression of base excision repair players, these generate different dna lesions of abasic sites of strand breaks

    Authors: Rusyn Ivan, Fry C Rebecca, Begley J Thomas et al.

    Organization: MIT Cambridge MA 02139 Country USA
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Associated Researchers

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Thought leaders and organizations working on research involving Zinc03995968.

View All Author iconAuthors
  • Himani Awasthi
  • Kashif Hanif
  • Santoshkumar Tota
  • L Zhu
  • Young Sook Kim
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Callisto Pharmaceuticals
  • National Cancer Institute (NCI)
  • James P. Wilmot Cancer Center
  • Celsion
  • FDA Office of Orphan Products Development
View All Affiliations icon Organizations
  • Central Drug Research Institute
  • Southern Illinois University School of Medicine
  • Hebrew University Hadassah Medical School
  • Universidad de Buenos Aires
  • Université de la Méditerranée

Clinical Trials | 29 trials

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