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Description: A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [PubChem]
Drug Type: Small Molecule; Experimental
Pharmacology: At the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3−) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
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Data Correlations | 7 studies

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Individual Studies

  • Expression data from normal adrenal gland and aldosterone-producing adenoma

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The source of aldosterone in 30 to 40 % of patients with primary hyperaldosteronism (PA) is unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated aldosterone production in APA are unknown. Herein, we examined expression of G-protein coupled receptors (GPCR) in APA and demon…

    Authors: Ye Ping, Rainey William

    Organization: Medical College of Georgia Physiology CA…

  • OMIM - Adrenal insufficiency

    Homo sapiens Homo sapiens | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving Zinc03833824.

View All Author iconAuthors
  • Mari K Nishizaka
  • Bradley A Maron
  • Eduardo Pimenta
  • Suzanne Oparil
  • Inmaculada Aban
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Vanderbilt University
  • National Taiwan University Hospital
  • Universidad Los Andes
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Department of Veterans Affairs
View All Affiliations icon Organizations
  • Boston University School of Medicine
  • Medical College of Georgia
  • University of Alabama - Birmingham
  • University of Queensland
  • 126 University Place

Clinical Trials | 196 trials

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