Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

Data Correlations | 1,139 studies

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Normal tissues	Score
Fat body	100
Deltoid	97
Hemisphere of cerebe…	90
Mucosa of mouth	84
Vermis of cerebellum	82
Globus pallidus	79

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Compounds	Score
2-deoxyglucose	100
Lycorine	80
Dibromoaminoanthraqu…	79
Phma	75
Butyric Acid	75
Naphthalene	74

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Diseases	Score
Multiple organ failu…	100
X-linked muscular dy…	100
Fibrous tissue neopl…	98
Rubinstein-Taybi syn…	95
Graft-versus-host di…	95
Injury of external e…	94

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Individual Studies
Gene expression profiling of experimental asthma induced by OVA challenge score: 100 | Mus musculus |   RNA Expression Three groups of mice (6 mice/group) were sensitized and challenged with allergen (OVA), one group (control group) was sensitized and challenged with placebo (PBS) and served as a control. Source: NextBio Library/Immune response and infection	Metastatic and primary breast tumors score: 81 | Homo sapiens |   RNA Expression Primary breast tumors, regional (lymph node) metastases, and distant metastases, ER positive and negative, and clinical grades of primary breast tumors. Source: NextBio Library/Oncology

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Literature | 9 results

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• AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.

  Authors: Jianxiong Jiang, Kodeeswaran Parameshwaran, M Lamar Seibenhener, Myoung-Goo Kang, Vishnu Suppiramaniam, Richard L Huganir, Maria T Diaz-Meco, Marie W Wooten

  Hippocampus 2009 Apr

• HYPERSENSITIVE TO RED AND BLUE 1, a ZZ-type zinc finger protein, regulates phytochrome B-mediated red and cryptochrome-mediated blue light responses.

  Authors: Xiaojun Kang, Jason Chong, Min Ni

  The Plant cell 2005 Mar

Associated Researchers

Thought leaders and organizations working on research involving Zinc finger, ZZ-type.

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• Jocelyn McCormick
• Jianxiong Jiang
• Myoung-Goo Kang
• John De Vos
• Lisa Thorson

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• Auburn University
• University of Minesota
• University of British Columbia
• University of Arizona
• Hiroshima University

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