Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

Data Correlations | 891 studies

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Normal tissues	Score
Quadriceps femoris	100
Pericardium	96
Superior vena cava	84
Substantia nigra	80
Vagina	79
Zygote	79

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Compounds	Score
Asparaginase	100
Proscillaridin	94
Ouabain	92
Concanavaline A	89
Butyric Acid	89
Dibromoaminoanthraqu…	89

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Diseases	Score
Fibrous tissue neopl…	100
Pre B-cell acute lym…	99
Common acute lymphob…	99
Erythema nodosum lep…	97
Androgen insensitivi…	96
Synovial like neopla…	95

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Individual Studies
Murine T cell response to IL-2 treatment score: 100 | Mus musculus |   RNA Expression The cytokine IL-2 determines T cell fate by controlling T cell proliferation and differentiation, but the expression files of IL-2 regulated genes are not defined Authors: Zhang Zhaoduo, Martino Anthony, Faulon Jean-Loup Organization: Sandia National Labs Biosystems 7011 Eas…	Microarray Innovations in LEukemia (MILE) study: Stage 1 data score: 100 | Homo sapiens |   RNA Expression 2096 blood or bone marrow samples of acute and chronic leukemia patients were hybridized to Affymetrix HG-U133 Plus 2.0 GeneChips. Source: NextBio Library/Oncology

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Literature | 5 results

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• ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.

  Authors: Christian B Gocke, Hongtao Yu

  PloS one 2008

• A microarray analysis of retinal transcripts that are controlled by image contrast in mice.

  Authors: Christine Brand, Frank Schaeffel, Marita Pauline Feldkaemper

  Molecular vision 2007

Associated Researchers

Thought leaders and organizations working on research involving Zinc finger, MYM-type.

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• Sylvie Tondeur
• William Fazzone
• John De Vos
• Frank Schaeffel
• Linda M Rehaume

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• University of Southern California
• Wellcome Trust Sanger Institute
• University of Texas Southwestern Medical Center
• University Eye Hospital Tuebingen
• Institute for Research in Biotherapy

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