Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

Data Correlations | 1,077 studies

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Normal tissues	Score
Superior vena cava	100
Femur	95
Cecum	94
Cardiac atrium	91
Substantia nigra	90
Uterine tube	89

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Compounds	Score
Monocrotaline	100
Nitrosomorpholine	99
Gamma Rays	96
P-dichlorobenzene	95
Dinitrofluorobenzene	94
1,25-dihydroxy-23-ox…	93

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Diseases	Score
Chronic hemorrhagic …	100
Benign neoplasm of f…	94
Tenosynovial giant c…	88
Encephalomyelitis	87
Primary cutaneous di…	81
Aggressive fibromato…	81

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Individual Studies
Testis from interspecific recombinant mice score: 100 | Mus musculus |   RNA Expression Analysis of the genomic expression profiles in interspecific recombinant congenic strains starting from a cross between Mus musculus and mus spretus. Source: NextBio Library/Atlas - Organs, tissues and cell types	SCC7 and NR-S1 murine tumors after C-ion or gamma irradiation score: 88 | Mus musculus |   RNA Expression C3H/HeMs male mice were irradiated by gamma-rays (30Gy, 50Gy, 70Gy) or carbon ions (30Gy) as local irradiation in single doses to hind legs where each tumor was transplanted. Authors: Nojiri Kazunori, Iwakawa Mayumi, Imadome Kaori et al. Organization: National Institute of Radiological Scien…

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Literature | 2 results

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• Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2.

  Authors: Michael D Tibbetts, Eric N Shiozaki, Lichuan Gu, E Robert McDonald, Wafik S El-Deiry, Yigong Shi

  Structure (London, England : 1993) 2004 Dec

• Alternative splicing and bioinformatic analysis of human U12-type introns.

  Authors: Wen-Cheng Chang, Yung-Chia Chen, Kuo-Ming Lee, Woan-Yuh Tarn

  Nucleic acids research 2007

Associated Researchers

Thought leaders and organizations working on research involving Zinc finger, FYVE-type.

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• Eric N Shiozaki
• Michael D Tibbetts
• Kuo-Ming Lee
• Wafik S El-Deiry
• Yung-Chia Chen

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• Graduate Institute of Life Sciences
• Princeton University

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