Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

Data Correlations | 1,141 studies

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Normal tissues	Score
Vagina	100
Myometrium	99
Superior cervical ga…	96
B lymphoblast	96
Superior surface of …	95
Ventral tegmental ar…	94

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Compounds	Score
Rituximab	100
Piperlonguminine	84
Dtt	81
Hydrogel	79
Thioguanosine	79
Zinc Chloride	76

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Diseases	Score
Primary cutaneous B-…	100
Pre B-cell acute lym…	98
Common acute lymphob…	98
Carcinoid tumor of l…	93
Aggressive fibromato…	93
Primary malignant cl…	91

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Individual Studies
Purkinje and granular cells from mice subjected to motor learning protocols score: 100 | Mus musculus |   RNA Expression Purkinje and granular cells from thirty-five adult (8-16 week old) C57BL/6 mice (which had undergone previous behavioral protocols). Organization: Stanford Microarray Database (SMD) Stanf…	Follicular lymphoma and normal lymphoid tissue comparisons score: 79 | Homo sapiens |   RNA Expression 20 Follicular lymphoma lymph node samples from 16 patients that had differing responses to treatment with rituximab were compared to four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Source: NextBio Library/Oncology

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Literature | 8 results

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• The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.

  Authors: E G Moss, R C Lee, V Ambros

  Cell 1997 Mar 7

• Inhibitory effects of archetypical nucleic acid ligands on the interactions of HIV-1 nucleocapsid protein with elements of Psi-RNA.

  Authors: Kevin B Turner, Nathan A Hagan, Daniele Fabris

  Nucleic acids research 2006

Associated Researchers

Thought leaders and organizations working on research involving Zinc finger, CCHC retroviral-type.

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• Hideo Yamagata
• Eric G Moss
• D W Martindale
• R C Lee
• M F Summers

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• University of Maryland Baltimore County
• Dartmouth College
• Université Louis Pasteur de Strasbourg
• McGill University
• University of Medicine and Dentistry of New Jersey

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