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Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

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Data Correlations | 127 studies

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Diseases category icon Diseases
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Anaplastic astrocyto… 100 100
Adenocarcinoma of es… 100 100
Undifferentiated car… 97 97
Nephrotoxic acute re… 94 94
Food deprivation 93 93
Drug toxicity 92 92
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Geneticperturbations category icon Gene perturbations
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CCND1 gene 100 100
APOB gene 97 97
AGR2 gene 97 97
HNF4A gene 96 96
LIPE gene 95 95
ANKRD2 gene 91 91
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Compounds category icon Compounds
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Ambroxol 100 100
Guanethidine 95 95
Bambuterol 93 93
Fipexide 92 92
Laudanosine 90 90
Taurine 87 87
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Individual Studies

  • Sex-dependent and HNF4alpha-dependent Mouse Liver Gene Expression

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Hepatocyte nuclear factor (HNF4alpha) is a liver-enriched transcription factor that regulates numerous liver-expressed genes. Presently, a liver-specific HNF4alpha-deficient mouse model was used to characterize the impact of liver HNF4alpha deficiency in female and male mice.

    Authors: Holloway G Minita, Miles D Gregory, Dombkowski A Alan et al.

    Organization: Boston University Department of Biology …

  • Melanocyte with inducible oncogenic receptor Xmrk stimulated with EGF

    score: 7979 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Mouse melanocytes transfected with an inducible version of the oncogenic receptor Xmrk (i.e. HER-mrk), were starved for 72 h and afterwards stimulated with EGF. We compared cells stimulated for 15 minutes, 1 hr, 2 hr, 4 hr, 8 hr or 24 hr, respectively, to unstimulated cells.

    Source: NextBio Library/Oncology
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Associated Researchers

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Thought leaders and organizations working on research involving Zinc finger, C2HC5-type.

View All Author iconAuthors
  • Peter H David
  • Serge Bonnefoy
  • Odile Mercereau-Puijalon
  • Caroline Proux
  • Emmanuel Bischoff
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  • Institut Pasteur

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