Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superf...

Data Correlations | 386 studies

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Normal tissues	Score
Corpus callosum	100
Preoptic area	95
Myometrium	86
Substantia nigra	85
Vestibular nuclear c…	84
Ganglion of cranial …	78

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Compounds	Score
Ornithine	100
Tetanus Toxin	94
Liposome	91
Dihydergot	89
Choleragen	88
Miconazole	87

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Diseases	Score
Benign neoplasm of f…	100
Tenosynovial giant c…	94
Carcinoid tumor of l…	94
Chronic hemorrhagic …	94
Aggressive fibromato…	89
Infertility due to a…	89

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Individual Studies

CD15 positive or negative medulloblastoma from mouse cerebellum score: 100 | Mus musculus |   RNA Expression To identify the molecular mechanisms that underlie tumor initiation and propagation, we will compare gene expression in tumors resulting from loss of patched in neural stem cells vs. progentors, and in cancer stem cells vs. non-cancer stem cells. Authors: Wechsler-Reya J Robert Organization: NIH Neuroscience Microarray Consortium N…

Developmental time course of whole ovary at gd 11, 12, 14, 16, 18 and pnd2. score: 79 | Mus musculus |   RNA Expression The overall objective of this proposal is to map the temporal and spatial dynamics of gene expression in the fetal mouse testis at key developmental timepoints Authors: Gaido K, Lehmann K Organization: MRC Human Genetics Unit GUDMAP Database …

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Literature | 16 results

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• X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation.

  Authors: E J Bellefroid, C Bourguignon, T Hollemann, Q Ma, D J Anderson, C Kintner, T Pieler

  Cell 1996 Dec 27

• Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.

  Authors: Sui Wang, Jia Zhang, Aizhen Zhao, Susan Hipkens, Mark A Magnuson, Guoqiang Gu

  Mechanisms of development 2007 Nov-Dec

Associated Researchers

Thought leaders and organizations working on research involving Zinc finger, C2HC-type.

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• Susan Hipkens
• A Akhtar
• Margarita Mauro-Herrera
• Long Ma
• K Higashi

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• Institut für Biochemie und Molekulare Zellbiologie
• Vanderbilt University Medical Center
• University of California
• Max-Delbrück-Centre for Molecular Medicine
• Ludwig-Maximilians-Universität

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