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Description: A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Cefotetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Mechanism of Action: The bactericidal action of cefotetan results from inhibition of cell wall synthesis.
Indication: For prophylaxis and treatment of bacterial infections.
Half Life: In volunteers with reduced renal function, the plasma half-life of cefotetan is prolonged
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Data Correlations | 1 study

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Genes category icon Genes
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PTPN20B 100 100
RPLP2 96 96
MAP7 94 94
C5orf23 92 92
RPL27 90 90
PPP2CB 89 89
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Biogroups category icon Biogroups
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G-secretase Mediated ERBB4 Signalin… 100 100
PML Pathway 99 99
Aspartic proteases 98 98
Transcriptional regulator SCAN 98 98
Dendritic Cells (DC) In Regulating … 97 97
RabGAP/TBC 97 97
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Yamatetan.

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  • Murray A Abramson
  • Erin H Jensen
  • Kamal M F Itani
  • Tyler S Finn
  • Samuel E Wilson
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Milano Bicocca
  • Stanford University
  • Teva Pharmaceuticals USA
  • Merck
  • Georgetown University
View All Affiliations icon Organizations
  • Creighton University School of Medicine
  • SUNY Downstate Medical Center
  • Sunlin Hospital
  • University of Kansas Medical Center
  • Emma Children's Hospital

Clinical Trials | 6 trials

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