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Xeroderma pigmentosum (XP) is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. People's skin cells with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP, showing anything from slight to extreme dysfunction in DNA excision repair. XP-G can be corrected by a 133 Kd nuclear protein, XPGC . XPGC is an acidic protein that confers normal UV resistance in expressing cells . It is a magnesium-dependent, single-...

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Data Correlations | 173 studies

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Tissues category icon Normal tissues
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Trachea 100 100
Spinal cord 90 90
Caudate nucleus 89 89
Adrenal gland 84 84
Thalamus 78 78
Thyroid gland 76 76
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Compounds category icon Compounds
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5-fluorouracil Arabi… 100 100
Pralidoxime 99 99
Lumicolchicine 95 95
Fusidic Acid 92 92
Vigabatrin 91 91
Chloropyramine 90 90
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Diseases category icon Diseases
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Xeroderma pigmentosu… 100 100
Hair-brain syndrome 88 88
Squamous cell carcin… 62 62
Grade I acute reject… 55 55
Dysplastic nevus 54 54
Metastasis from mali… 53 53
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Individual Studies

  • Normal tissues transcriptome_Hs: Relative gene expression

    score: 100100 | Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human samples across a diverse array of tissues, organs, and cell lines.

    Authors: Su AI, Cooke MP, Ching KA et al.

    Organization: Genomics Institute of the Novartis Resea…

  • Mouse Phenotypes - Xeroderma pigmentosum

    score: 9090 | Mus musculus Mus musculus | Mutations/Phenotypic   Mutations/Phenotypic

    This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni…

    Source: NextBio Library/Mutation and Phenotypic data
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Associated Researchers

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Thought leaders and organizations working on research involving Xeroderma pigmentosum group D protein.

View All Author iconAuthors
  • Kenneth H Kraemer
  • Sikandar G Khan
  • Deborah Hoogstraten
  • Jan H J Hoeijmakers
  • Wim Vermeulen
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  • National Taiwan University Hospital
View All Affiliations icon Organizations
  • Institut de Génétique et de Biologie Moléculaire et Cellulaire
  • University of Illinois at Urbana-Champaign
  • Erasmus University
  • University of St. Andrews
  • University of Texas M.D. Anderson Cancer Center

Clinical Trials | 2 trials

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