Xeroderma pigmentosum (XP) is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. People's skin cells with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP, showing anything from slight to extreme dysfunction in DNA excision repair. XP-G can be corrected by a 133 Kd nuclear protein, XPGC . XPGC is an acidic protein that confers normal UV resistance in expressing cells . It is a magnesium-dependent, single-...

Data Correlations | 1,013 studies

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Normal tissues	Score
Globus pallidus	100
Penis	97
Subthalamic nucleus	81
Thymus	80
Adrenal gland	76
Caudate nucleus	74

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Compounds	Score
Oxygen	100
Phorbol Ester	97
Dasatinib	88
[14c] Alpha-amino-be…	85
Transferrin	84
Thymidine	84

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Diseases	Score
Limited scleroderma	100
Dermal metastasis	93
cancer of fallopian …	87
Acute HIV infection	85
Adrenal carcinoma	80
Melanoma of skin	79

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Individual Studies

Breast cancer cell lines treated with doxorubicin and p53-RNAi score: 100 | Homo sapiens |   RNA Expression p53-dependent gene expression signatures of four cell lines (MCF-7, ZR-75-1, and two immortalized human mammary epithelial cell lines) were identified by comparing p53-RNAi transduced cell lines to their parent cell lines. Organization: University of North Carolina at Chapel H…

Granulocytic differentiation of primary CD34+ cells cultured under 5% and 20% O2 levels score: 95 | Homo sapiens |   RNA Expression We examined the transcriptional profile of G differentiation of human CD34-positive hematopoietic stem and progenitor cells cultured with interleukin-3, interleukin-6 granulocyte colony stimulating factor and stem cell factor. Organization: Northwestern University Chemical and Bio…

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Literature | 195 results

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• XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients.

  Authors: Shinsuke Ito, Isao Kuraoka, Pierre Chymkowitch, Emmanuel Compe, Arato Takedachi, Chie Ishigami, Frédéric Coin, Jean-Marc Egly, Kiyoji Tanaka

  Molecular cell 2007 Apr 27

• Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polymerase lambda and RPA subunit proteins, is involved in cell proliferation.

  Authors: Tomoyuki Furukawa, Tomohiro Imamura, Hiroko K Kitamoto, Hiroaki Shimada

  Plant molecular biology 2008 Mar

Associated Researchers

Thought leaders and organizations working on research involving XPG I.

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• Kengo Sakaguchi
• Isabelle Dunand-Sauthier
• Tomoyuki Furukawa
• Seisuke Kimura
• Stuart G Clarkson

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• University Medical Centre
• Tokyo University of Science
• University of Texas M.D. Anderson Cancer Center
• Osaka University
• Nagoya University

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