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Description: An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.
Mechanism of Action: Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.
Indication: For management of High blood pressure
Half Life: 6 hours.
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Data Correlations | 2 studies

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Genes category icon Genes
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ADRA2A 100 100
CTSS 97 97
S100A8 90 90
ANP32A 90 90
S100A7 88 88
ATM 87 87
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Biogroups category icon Biogroups
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ARF/SAR superfamily 100 100
I43 - oprin 99 99
RNA-directed DNA polymerase (revers… 99 99
Cytochrome P450, E-class, group I 98 98
SEA Protein Family 98 98
IL-18 Pathway 98 98
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving Wy 8678.

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  • A T Shropshire
  • T Baum
  • K Akatsuka
  • T Hashimoto
  • K Takeuchi

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