Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

Data Correlations | 92 studies

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Diseases	Score
Streptococcal pneumo…	100
African trypanosomia…	93
Huntington's disease	87
Cytomegalovirus infe…	86
General adaptation s…	84
Metastases	62

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Gene perturbations	Score
JMJD1A gene	100
JMJD2C gene	87
NDST2 gene	75
NDST1 gene	75
ESRRB gene	74
ANKRD2 gene	63

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Compounds	Score
Su5402	100
Sodium Chlorate	91
Nsc673924	73
Piromidic Acid	67
Oxolamine	66
Naloxone	64

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Individual Studies
Jmjd1a and Jmjd2c RNAi in Mouse Stem Cells score: 100 | Mus musculus |   RNA Expression We used microarrays to detail the global programme of gene expression after silencing Jmjd1a gene and Jmjd2c gene separately. Authors: Loh Yuin-Han, Zhang Weiwei, Chen Xi et al. Organization: Genone Institute of Singapore Stem Cell …	Global gene-expression analyses of the Esrrb reprogrammed and knockdown cells score: 96 | Mus musculus |   RNA Expression Global gene expression analysis of mouse embryonic fibroblasts induced to pluripotency by transcription factor, Esrrb, and Esrrb knockdown MEF's. Authors: Feng B, Jiang J, Kraus P et al. Organization: Genome Institute of Singapore 60 Biopoli…

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Literature | 49 results

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• A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.

  Authors: I-Chun Tsai, Jeffrey D Amack, Zhong-Hua Gao, Vimla Band, H Joseph Yost, David M Virshup

  Developmental cell 2007 Mar

• Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

  Authors: S Wang, M Krinks, K Lin, F P Luyten, M Moos

  Cell 1997 Mar 21

Associated Researchers

Thought leaders and organizations working on research involving Wnt-8 protein.

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• Masaru Katoh
• R T Moon
• Tetsuroh Saitoh
• J R Miller
• M Krinks

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• National Cancer Center Research Institute
• University of Washington School of Medicine
• University of Utah
• Laboratory of Developmental Biology
• University Hospital of Freiburg

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