Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

Data Correlations | 318 studies

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Normal tissues	Score
Temporal lobe	100

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Compounds	Score
Dibutyl Phthalate	100
Phenylalanine Amide	96
H00920000	95
Vanadium Pentoxide	93
Nickel Dichloride	86
Mehp	80

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Diseases	Score
Androgen insensitivi…	100
Benign neoplasm of f…	86
Toxoplasmosis	83
Chronic hemorrhagic …	81
Aggressive fibromato…	77
Synovial like neopla…	71

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Individual Studies

Fibroblasts from genital and extragenital regions of 46,XY individuals score: 100 | Homo sapiens |   RNA Expression Global gene expression profiles in genital-derived fibroblasts that differ between 46, XY males and 46, XY females with complete androgen insensitivity syndrome (CAIS) due to inactivating mutations of the androgen receptor (AR). Authors: Holterhus P Organization: Universitätsklinikum Schleswig-Holstein …

Genital fibroblasts from 46,XY individuals with WT AR or germline inactivation of AR score: 99 | Homo sapiens |   RNA Expression To gain insights into the role of androgen in genital morphogenesis, we compared basal transcriptional patterns in genital fibroblasts from 46,XY individuals with either wild-type AR or germline inactivation of the AR as a result of mutation. Authors: Holterhus Paul-Martin Organization: Stanford Microarray Database (SMD) Stanf…

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Literature | 101 results

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• Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.

  Authors: Gary A Wayman, Soren Impey, Daniel Marks, Takeo Saneyoshi, Wilmon F Grant, Victor Derkach, Thomas R Soderling

  Neuron 2006 Jun 15

• Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.

  Authors: Liang You, Biao He, Zhidong Xu, Kazutsugu Uematsu, Julien Mazieres, Iwao Mikami, Noemi Reguart, Terry W Moody, Jan Kitajewski, Frank McCormick,…

  Oncogene 2004 Aug 12

Associated Researchers

Thought leaders and organizations working on research involving Wnt-2 protein.

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• Biao He
• Iwao Mikami
• Zhidong Xu
• David M Jablons
• A Yaniv

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• University of California
• Indiana University
• Yale University School of Medicine
• Tel Aviv University
• Oregon Health and Science University

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