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Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

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Data Correlations | 120 studies

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Diseases category icon Diseases
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Postpartum cardiomyo… 100 100
Blindness of one eye 68 68
Not getting enough s… 61 61
Age-associated memor… 60 60
Facioscapulohumeral … 56 56
Arthritis 54 54
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Geneticperturbations category icon Gene perturbations
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NFIC gene 100 100
PKD1 gene 93 93
TSC2 gene 85 85
Nfe2l2 gene 82 82
ras gene 80 80
GAST gene 79 79
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Compounds category icon Compounds
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Procyanidin 100 100
Deamino Arginine Vas… 98 98
Gsh 97 97
Sulfur Mustard Agent… 95 95
Bpde 80 80
Zinc00901555 78 78
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Individual Studies

  • Effect of Actin cytoskeleton abnormalities due to DSTN deficiency on cornea

    score: 6969 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    A spontaneous mouse mutant, corneal disease 1 (corn1), is deficient for a regulator of actin dynamics, destrin, and develops epithelial hyperproliferation and neovascularization in the cornea. To examine the effect of the Dstncorn1 mutation on gene expression, we performed a microarray analysis usin…

    Authors: Verdoni M Angela, Aoyama Natsuyo, Ikeda Akihiro et al.

    Organization: University of Wisconsin-Madison Departme…
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Associated Researchers

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Thought leaders and organizations working on research involving Wnt-14 protein.

View All Author iconAuthors
  • Lachlan M Carter
  • S Y Park
  • A F Broccard
  • O Türeci
  • Anthony D Person
View All Affiliations icon Organizations
  • Harvard Medical School
  • Brigham and Women's Hospital
  • University Medical Center
  • Dalhousie University
  • Thomas Jefferson University College of Medicine

Community

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