Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

Data Correlations | 224 studies

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Normal tissues	Score
Caudate nucleus	100
Uterus	81
Amygdala	66
Lung	63
Kidney	54
Cerebral cortex	53

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Compounds	Score
Cefotaxime	100
Cloxacillin	94
Carbohydrates And Su…	92
Santonin	90
Iobenguane I 123	89
Vanadium(v) Oxide	86

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Diseases	Score
Conn syndrome	100
Osteosarcoma of bone	87
Roberts-SC phocomeli…	86
Primary malignant cl…	86
Human papilloma viru…	83
Pilocytic astrocytom…	82

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Individual Studies

Mouse Stromal Response to Tumor Invasion score: 100 | Mus musculus |   RNA Expression Primary and metastatic tumor growth induce host tissue responses that are believed to support tumor progression. Understanding the molecular changes within the tumor microenvironment during tumor progression may therefore be relevant not only for discovering potential therapeutic targets but also fo… Authors: Bacac Marina, Provero Paolo, Mayran Nathalie et al. Organization: University of Turin Genetics, Biology an…

Time course of glucocortiocid receptor isoforms score: 91 | Homo sapiens |   RNA Expression Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanis… Authors: Lu Z Nick, Collins B Jennifer, Grissom F Sherry et al. Organization: NIEHS DIR NMG 111 T.W. Alexander Drive R…

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Literature | 28 results

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• Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells.

  Authors: Ujunwa C Okoye, Craig C Malbon, Hsien-Yu Wang

  Journal of molecular signaling 2008

• Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast.

  Authors: Ying Zhou, Haiping Kou, Zhigang Wang

  Nucleic acids research 2007

Associated Researchers

Thought leaders and organizations working on research involving Wnt-10 protein.

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• A W Thomson
• M A Antonysamy
• V M Subbotin
• R J Steptoe
• A Khanna

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• University of Pittsburgh
• Stanford University School of Medicine
• State University of New York at Stony Brook
• University of Kentucky
• Institute of Microbiology

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