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Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) . It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals . Wnt signalling has been implicated in tumorigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

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Data Correlations | 898 studies

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Tissues category icon Normal tissues
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Nipple 100 100
Mucosa of pharynx 94 94
Superior vena cava 92 92
Vulva 88 88
Substantia nigra par… 87 87
Lateral nuclear grou… 87 87
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Compounds category icon Compounds
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Cadmium Sulfate 100 100
Dibutyl Phthalate 86 86
1,25-dihydroxy-23-ox… 85 85
Ganciclovir 84 84
Tgfbeta 84 84
Alpha-melanotropin 81 81
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Diseases category icon Diseases
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Androgen insensitivi… 100 100
Spontaneous abortion 92 92
Benign neoplasm of f… 90 90
Chronic hemorrhagic … 90 90
Aggressive fibromato… 89 89
Toxoplasmosis 89 89
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Individual Studies

  • Mouse Stromal Response to Tumor Invasion

    score: 100100 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Primary and metastatic tumor growth induce host tissue responses that are believed to support tumor progression. Understanding the molecular changes within the tumor microenvironment during tumor progression may therefore be relevant not only for discovering potential therapeutic targets but also fo…

    Authors: Bacac Marina, Provero Paolo, Mayran Nathalie et al.

    Organization: University of Turin Genetics, Biology an…

  • Testis from interspecific recombinant mice

    score: 5050 | Mus musculus Mus musculus | RNA Expression   RNA Expression

    Analysis of the genomic expression profiles in interspecific recombinant congenic strains starting from a cross between Mus musculus and mus spretus.

    Source: NextBio Library/Atlas - Organs, tissues and cell types
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Associated Researchers

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Thought leaders and organizations working on research involving Wnt superfamily.

View All Author iconAuthors
  • Rocky S Tuan
  • Hsien-Yu Wang
  • Craig C Malbon
  • Mary B Goldring
  • Rik J U Lories
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • University of Utah
View All Affiliations icon Organizations
  • State University of New York at Stony Brook
  • National Institute of Arthritis
  • Katholieke Universiteit Leuven
  • MRC Laboratory of Molecular Biology
  • University of Padua

Clinical Trials | 1 trial

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Community

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