A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.

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• Selective release of molecules from Weibel-Palade bodies during a lingering kiss.

  Authors: Victor Babich, Athinoula Meli, Laura Knipe, John E Dempster, Paul Skehel, Matthew J Hannah, Tom Carter

  Blood 2008 Jun 1

• Formation and function of Weibel-Palade bodies.

  Authors: Daniel J Metcalf, Thomas D Nightingale, Helen L Zenner, Winnie W Lui-Roberts, Daniel F Cutler

  Journal of cell science 2008 Jan 1

Associated Researchers

Thought leaders and organizations working on research involving Weibel-Palade body.

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• Daniel F Cutler
• Matthew J Hannah
• Jan Voorberg
• Munekazu Yamakuchi
• Charles J Lowenstein

View All Organizations

• University College London
• Johns Hopkins University School of Medicine
• University of Amsterdam
• Tumor Biology Center
• Medical College of Wisconsin

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