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WW domain containing oxidoreductase
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor ...
Normal tissues
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|---|---|---|---|
| Nipple |
100
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| Hemisphere of cerebe… |
98
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| Thyroid gland |
92
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| Vermis of cerebellum |
91
|
||
| Globus pallidus |
90
|
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| Subthalamic nucleus |
88
|
Compounds
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|---|---|---|---|
| Polyamide Ii |
100
|
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| Camptothecin |
79
|
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| Androstanolone |
75
|
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| O-methyleugenol |
72
|
||
| 2-nitrotoluene |
71
|
||
| P-nitrotoluene |
69
|
 Individual Studies |
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Homo sapiens
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RNA Expression
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WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.
Authors: Charlie Gourley, Adam J W Paige, Karen J Taylor, Carol Ward, Barbara Kuske, Jieqing Zhang, Mingjun Sun, Szymon Janczar, David J Harrison, Morwenna Muir,…
Cancer research 2009 Jun 1 -
Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.
Authors: Rami I Aqeilan, John P Hagan, Haifa A Aqeilan, Flavia Pichiorri, Louise Y Y Fong, Carlo M Croce
Cancer research 2007 Jun 15
Thought leaders and organizations working on research involving WWOX.
- Ohio State University
- Hacettepe University
- Centre René Huguenin
- Thomas Jefferson University
- University of Texas M. D. Anderson Cancer Center
