WRN - NextBio

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Search Term: WRN (gene)

Overview

Werner syndrome, RecQ helicase-like

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werne...

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Data Correlations | 1,059 studies

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Normal tissues

Score

Femur

100

Great saphenous vein

Synovial membrane

Subdivision of nucle…

Vermis of cerebellum

Caudate nucleus

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Compounds

Score

Isoadrenaline

100

Iodipamide

Seneciphyllin

Arecoline

Spamol

Sulfachlorpyridazine

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Diseases

Score

Werner syndrome

100

Osteosarcoma of bone

Intracranial meningi…

Cardiac transplant r…

Infection by Aspergi…

Compression injury o…

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Individual Studies
Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…	OMIM - Congenital disorder score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

Individual Studies

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…

OMIM - Congenital disorder

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data