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Description: Tricyclic antidepressant similar in action and side effects to imipramine. It may produce excitation. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Protriptyline is a tricyclic antidepressant. It was thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.
Mechanism of Action: Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
Indication: For the treatment of depression and obsessive-compulsive disorders.
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Data Correlations | 5 studies

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Genes category icon Genes
Score Help
SLC6A4 100 100
SLC6A2 100 100
HSPA5 100 100
FPR1 92 92
IFI6 92 92
84981 90 90
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Biogroups category icon Biogroups
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Aminosugars Metabolism 100 100
Cholesterol Biosynthesis 100 100
Biosynthesis of Steroids 99 99
ADP-Ribosylation Factor Pathway 98 98
Terpenoid Biosynthesis 98 98
Protein of unknown function DUF1220 98 98
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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving Vivactil.

View All Author iconAuthors
  • F Sériès
  • Y Cormier
  • Ulysses J Magalang
  • Y Huang
  • B V Vaughn
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Roxane Laboratories
  • Emory University
  • Memorial Sloan-Kettering Cancer Center
  • Schering-Plough
  • University of Nebraska
View All Affiliations icon Organizations
  • Université Laval
  • Papworth Hospital
  • Hôpital Laval
  • Chinese University of Hong Kong
  • Kangwon National University College of Medicine

Clinical Trials | 17 trials

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