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Description: A calcium channel blocker that is a class IV anti-arrhythmia agent. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Mechanism of Action: Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, verapamil, like diltiazem, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries,improved oxygen delivery to the myocardial tissue, and decreased total peripheral resistance, systemic blood pressure, and afterload.
Indication: For the treatment of hypertension and angina.
Half Life: 2.8-7.4 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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SCN5A 100 100
CA1 100 100
EID1 100 100
ATM 99 99
CSNK2A1 98 98
BUB1 95 95
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Biogroups category icon Biogroups
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Ubiquitin Mediated Proteolysis 100 100
Activation of cAMP-dependent Protei… 99 99
Ubiquinone Biosynthesis 99 99
Histone core 99 99
Sulfur Metabolism 98 98
High mobility group protein HMG14 a… 98 98
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Individual Studies

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Associated Researchers

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Thought leaders and organizations working on research involving Verapamil.

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  • Michael A Strauss
  • Fabian Walter
  • Joong-Hwa Chung
  • Carl J Pepine
  • Scott J Denardo
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  • Abbott
  • Mylan Pharmaceuticals
  • Medical University of Silesia
  • Assistance Publique - Hôpitaux de Paris
  • AstraZeneca
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  • Chosun University
  • University of Alabama - Birmingham
  • Max-Planck-Institut für Astronomie
  • Indiana University School of Medicine
  • CBR Institute for Biomedical Research

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